2255338-25-9

2255338-25-9 structure

Name: SGC-iMLLT
Chemical Name: SGC-iMLLT
CAS Number: 2255338-25-9
Molecular Formula: C₂₂H₂₄N₆O
Molecular Weight: 388.47
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-06-04 18:13:27
Modify Date: 2024-02-04 11:19:45
SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1].

Name	SGC-iMLLT

Description	SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	IC50: 0.26 μM (MLLT1 YD)[1] Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]
References	[1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307.