1254733-98-6

1254733-98-6 structure

Name: SSTR5 antagonist 2 TFA
Chemical Name: SSTR5 antagonist 2 TFA
CAS Number: 1254733-98-6
Molecular Formula: C₃₄H₃₆F₄N₂O₇
Molecular Weight: 660.65
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2019-06-01 23:49:45
Modify Date: 2024-01-04 12:10:45
SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential to treat type 2 diabetes mellitus (T2DM)[1].

Name	SSTR5 antagonist 2 TFA

Description	SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential to treat type 2 diabetes mellitus (T2DM)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Metabolic Disease
Target	SSTR5[1].
In Vivo	SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1]. SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1]. Animal Model: Rodent diabetic model without risk of hypoglycemia[1]. Dosage: 10 mg/kg. Administration: Orally. Result: Increased both total and active circulating incretin hormone GLP1 levels.
References	[1]. Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087.

Molecular Formula	C₃₄H₃₆F₄N₂O₇
Molecular Weight	660.65