1834571-04-8

1834571-04-8 structure

Name: Tat-NR2B9c TFA
Chemical Name: Tat-NR2B9c TFA
CAS Number: 1834571-04-8
Molecular Formula: C₁₀₇H₁₈₉F₃N₄₂O₃₂
Molecular Weight: 2632.90
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2019-06-01 13:08:12
Modify Date: 2024-01-16 16:35:04
Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].

Name	Tat-NR2B9c TFA

Description	Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Neurological Disease
Target	EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1] p38[2]
References	[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.