2139287-33-3
2139287-33-3 structure
- Name: THAL SNS 032
- Chemical Name: THAL-SNS-032
- CAS Number: 2139287-33-3
- Molecular Formula: C40H52N8O10S2
- Molecular Weight: 869.02
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2019-06-01 12:51:41
- Modify Date: 2025-08-26 10:04:32
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THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
| Name | THAL-SNS-032 |
|---|
| Description | THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK9[1] |
| In Vitro | THAL-SNS-032 selectively induces degradation of CDK9[1]. THAL-SNS-032 diminishes elongating polymerase II[1]. THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1]. |
| References |
| Molecular Formula | C40H52N8O10S2 |
|---|---|
| Molecular Weight | 869.02 |