DC Chemicals Limited
China
Product Name: THAL-SNS-032
Price: $800.0/100mg $1500.0/250mg $3000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2139287-33-3

2139287-33-3 structure

2139287-33-3 structure

Name: THAL SNS 032
Chemical Name: THAL-SNS-032
CAS Number: 2139287-33-3
Molecular Formula: C₄₀H₅₂N₈O₁₀S₂
Molecular Weight: 869.02
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2019-06-01 12:51:41
Modify Date: 2024-01-04 11:57:31
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].

Name	THAL-SNS-032

Description	THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC
Target	CDK9[1]
In Vitro	THAL-SNS-032 selectively induces degradation of CDK9[1]. THAL-SNS-032 diminishes elongating polymerase II[1]. THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
References	[1]. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.

Molecular Formula	C₄₀H₅₂N₈O₁₀S₂
Molecular Weight	869.02