THAL SNS 032

Modify Date: 2024-01-04 11:57:31

THAL SNS 032 structure	Common Name	THAL SNS 032
	CAS Number	2139287-33-3	Molecular Weight	869.02
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₅₂N₈O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of THAL SNS 032

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].

Name	THAL-SNS-032

Description	THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC
Target	CDK9[1]
In Vitro	THAL-SNS-032 selectively induces degradation of CDK9[1]. THAL-SNS-032 diminishes elongating polymerase II[1]. THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
References	[1]. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.

Molecular Formula	C₄₀H₅₂N₈O₁₀S₂
Molecular Weight	869.02

DC Chemicals Limited
China
Product Name: THAL-SNS-032
Price: $800.0/100mg $1500.0/250mg $3000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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THAL SNS 032 Biological Activity

Chemical & Physical Properties