THAL SNS 032
Modify Date: 2025-08-26 10:04:32
THAL SNS 032 structure
|
Common Name | THAL SNS 032 | ||
|---|---|---|---|---|
| CAS Number | 2139287-33-3 | Molecular Weight | 869.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H52N8O10S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of THAL SNS 032THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1]. |
| Name | THAL-SNS-032 |
|---|
| Description | THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK9[1] |
| In Vitro | THAL-SNS-032 selectively induces degradation of CDK9[1]. THAL-SNS-032 diminishes elongating polymerase II[1]. THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1]. |
| References |
| Molecular Formula | C40H52N8O10S2 |
|---|---|
| Molecular Weight | 869.02 |