THAL SNS 032

Modify Date: 2025-08-26 10:04:32

THAL SNS 032 structure	Common Name	THAL SNS 032
	CAS Number	2139287-33-3	Molecular Weight	869.02
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₅₂N₈O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of THAL SNS 032

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].

Name	THAL-SNS-032

Description	THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PROTAC >> PROTAC
Target	CDK9[1]
In Vitro	THAL-SNS-032 selectively induces degradation of CDK9[1]. THAL-SNS-032 diminishes elongating polymerase II[1]. THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
References	[1]. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.

Molecular Formula	C₄₀H₅₂N₈O₁₀S₂
Molecular Weight	869.02

Name: Thermodynamic solubility of the compound in phosphate buffer at pH 7 incubated for 1 ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5105246

Name: Thermal Shift Assay. Domain start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL4650107

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Induction of CDK9/CyclinT1 degradation in human U2932 cells at 100 nM measured after ...
Source: ChEMBL
Target: Cyclin-dependent kinase 9
External Id: CHEMBL5367571

Name: Inhibition of GST-fused human full-length CDK9 (1 to 372(end) residues)/N-terminal GS...
Source: ChEMBL
Target: Cyclin-dependent kinase 9
External Id: CHEMBL5367569

Name: Cytotoxicity against human U2932 cells assessed as inhibition of cell growth measured...
Source: ChEMBL
Target: U2932
External Id: CHEMBL5367570

Name: Inhibition of GST-fused human full-length CDK9 (1 to 372(end) residues)/N-terminal GS...
Source: ChEMBL
Target: Cyclin-dependent kinase 9
External Id: CHEMBL5367568

Name: Inhibition of colony formation in human 22Rv1 cells at 100 to 200 nM treated for 14 d...
Source: ChEMBL
Target: CWR22R
External Id: CHEMBL5118754

Name: Induction of cell cycle arrest in human 22Rv1 cells assessed as accumulation of cells...
Source: ChEMBL
Target: CWR22R
External Id: CHEMBL5118755

Name: Induction of cell cycle arrest in human 22Rv1 cells assessed as accumulation of cells...
Source: ChEMBL
Target: CWR22R
External Id: CHEMBL5118756

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.