Shanghai Nianxing Industrial Co., Ltd
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Product Name: Top1 inhibitor 1
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2302772-05-8

2302772-05-8 structure

2302772-05-8 structure

Name: Top1 inhibitor 1
Chemical Name: Top1 inhibitor 1
CAS Number: 2302772-05-8
Molecular Formula: C₂₄H₂₂N₆O₂
Molecular Weight: 426.47
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2019-06-01 16:47:56
Modify Date: 2025-08-25 21:04:14
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].

Name	Top1 inhibitor 1

Description	Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	IC50: 29 nM (human topoisomerase I)[1]
In Vitro	Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1].
References	[1]. Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62(7):3428-3446.

Molecular Formula	C₂₄H₂₂N₆O₂
Molecular Weight	426.47

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