1809085-30-0

1809085-30-0 structure

Name: VU 0650786
Chemical Name: VU0650786
CAS Number: 1809085-30-0
Molecular Formula: C₁₈H₁₅ClFN₅O₂
Molecular Weight: 387.80
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-06-02 00:47:27
Modify Date: 2024-01-10 15:06:32
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].

Name	VU0650786

Description	VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR3:392 nM (IC50)
References	[1]. Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.