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2247544-02-9

2247544-02-9 structure
2247544-02-9 structure
  • Name: WS-383 hydrochloride
  • Chemical Name: WS-383
  • CAS Number: 2247544-02-9
  • Molecular Formula: C18H21Cl2N9S2
  • Molecular Weight: 498.46
  • Catalog: Research Areas Cancer
  • Create Date: 2019-06-01 23:06:08
  • Modify Date: 2025-08-25 19:11:36
  • WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].

Name WS-383
Description WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
Related Catalog
Target

IC50: 11 nM (DCN1-UBC12 interaction)[1]

References

[1]. Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797.

Molecular Formula C18H21Cl2N9S2
Molecular Weight 498.46
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