WS-383 hydrochloride

Modify Date: 2025-08-25 19:11:36

WS-383 hydrochloride Structure
WS-383 hydrochloride structure
Common Name WS-383 hydrochloride
CAS Number 2247544-02-9 Molecular Weight 498.46
Density N/A Boiling Point N/A
Molecular Formula C18H21Cl2N9S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WS-383 hydrochloride


WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].

 Names

Name WS-383

 WS-383 hydrochloride Biological Activity

Description WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].
Related Catalog
Target

IC50: 11 nM (DCN1-UBC12 interaction)[1]

References

[1]. Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797.

 Chemical & Physical Properties

Molecular Formula C18H21Cl2N9S2
Molecular Weight 498.46
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