926906-64-1

926906-64-1 structure

Name: VRX-0466617
Chemical Name: VRX-0466617
CAS Number: 926906-64-1
Molecular Formula: C₁₉H₂₀BrN₅O₂S
Molecular Weight: 462.36
Catalog: Signaling Pathways Cell Cycle/DNA Damage Checkpoint Kinase (Chk)
Create Date: 2019-08-07 19:49:23
Modify Date: 2024-01-08 20:20:58
VRX0466617, a selective Chk2 inhibitor, inhibits the phosphorylation of Chk2 Ser 19 and Ser33-35. VRX0466617 can be used in the study of cancer[1].

Name	VRX-0466617
Synonyms	5-({4-[(4-bromophenyl)amino]phenyl}amino)-3-hydroxy-N-(1-hydroxypropan-2-yl)-1,2-thiazole-4-carboximidamide 4-Isothiazolecarboximidamide, 5-[[4-[(4-bromophenyl)amino]phenyl]amino]-2,3-dihydro-N-(2-hydroxy-1-methylethyl)-3-oxo- 5-({4-[(4-Bromophenyl)amino]phenyl}amino)-N-(1-hydroxy-2-propanyl)-3-oxo-2,3-dihydro-1,2-thiazole-4-carboximidamide

Description	VRX0466617, a selective Chk2 inhibitor, inhibits the phosphorylation of Chk2 Ser 19 and Ser33-35. VRX0466617 can be used in the study of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Checkpoint Kinase (Chk)
References	[1]. Carlessi L, et al. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther. 2007 Mar;6(3):935-44.