2121515-37-3

2121515-37-3 structure

Name: c-Kit-IN-2
Chemical Name: c-Kit-IN-2
CAS Number: 2121515-37-3
Molecular Formula: C₂₅H₂₉N₉O₂S
Molecular Weight: 519.62
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Kit
Create Date: 2019-06-30 07:11:05
Modify Date: 2024-01-11 11:30:42
c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].

Name	c-Kit-IN-2

Description	c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
Target	IC50: 82 nM (c-KIT)[1]
References	[1]. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957.

Molecular Formula	C₂₅H₂₉N₉O₂S
Molecular Weight	519.62