c-Kit-IN-2

Modify Date: 2025-08-25 19:06:19

c-Kit-IN-2 Structure
c-Kit-IN-2 structure
Common Name c-Kit-IN-2
CAS Number 2121515-37-3 Molecular Weight 519.62
Density N/A Boiling Point N/A
Molecular Formula C25H29N9O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of c-Kit-IN-2


c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].

 Names

Name c-Kit-IN-2

 c-Kit-IN-2 Biological Activity

Description c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].
Related Catalog
Target

IC50: 82 nM (c-KIT)[1]

References

[1]. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957.

 Chemical & Physical Properties

Molecular Formula C25H29N9O2S
Molecular Weight 519.62
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