2270879-07-5
2270879-07-5 structure
- Name: CHMFL-ABL-121
- Chemical Name: CHMFL-ABL-121
- CAS Number: 2270879-07-5
- Molecular Formula: C30H31F3N6OS
- Molecular Weight: 580.67
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
- Create Date: 2019-07-01 07:06:15
- Modify Date: 2025-08-25 18:14:57
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CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].
| Name | CHMFL-ABL-121 |
|---|
| Description | CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
ABL wt:2 nM (IC50) |
| In Vitro | CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50 < 10 nM),MEG-01 (EC50 < 10 nM) and KU812 (EC50 < 30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1]. CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1]. |
| References |
| Molecular Formula | C30H31F3N6OS |
|---|---|
| Molecular Weight | 580.67 |