CHMFL-ABL-121

Modify Date: 2025-08-25 18:14:57

CHMFL-ABL-121 structure	Common Name	CHMFL-ABL-121
	CAS Number	2270879-07-5	Molecular Weight	580.67
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₁F₃N₆OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CHMFL-ABL-121

CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].

Name	CHMFL-ABL-121

Description	CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
Target	ABL wt:2 nM (IC50)
In Vitro	CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50 < 10 nM),MEG-01 (EC50 < 10 nM) and KU812 (EC50 < 30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1]. CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1].
References	[1]. Liu X, et al. Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia. Eur J Med Chem. 2018 Dec 5;160:61-81.

Molecular Formula	C₃₀H₃₁F₃N₆OS
Molecular Weight	580.67

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CHMFL-ABL-121
Price: Check
Purity: 99.86%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

CHMFL-ABL-121 suppliers

CHMFL-ABL-121 price