CHMFL-ABL-121 structure
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Common Name | CHMFL-ABL-121 | ||
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CAS Number | 2270879-07-5 | Molecular Weight | 580.67 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C30H31F3N6OS | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of CHMFL-ABL-121CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1]. |
Name | CHMFL-ABL-121 |
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Description | CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1]. |
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Related Catalog | |
Target |
ABL wt:2 nM (IC50) |
In Vitro | CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50 < 10 nM),MEG-01 (EC50 < 10 nM) and KU812 (EC50 < 30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1]. CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1]. |
References |
Molecular Formula | C30H31F3N6OS |
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Molecular Weight | 580.67 |