1345839-28-2

1345839-28-2 structure

Name: EIPA hydrochloride
Chemical Name: EIPA hydrochloride
CAS Number: 1345839-28-2
Molecular Formula: C₁₁H₁₉Cl₂N₇O
Molecular Weight: 336.22
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2019-06-29 17:18:05
Modify Date: 2024-01-09 21:31:13
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM[1]. EIPA also inhibits Na+/H+-exchanger (NHE)[2] and macropinocytosis[3].

Name	EIPA hydrochloride

Description	EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM[1]. EIPA also inhibits Na+/H+-exchanger (NHE)[2] and macropinocytosis[3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	IC50: 10.5 μM (TRPP3 channel)[1] NHE[2] Macropinocytosis[3]
References	[1]. Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85. [2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429. [3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.