1646682-14-5

1646682-14-5 structure

Name: FD-IN-1
Chemical Name: FD-IN-1
CAS Number: 1646682-14-5
Molecular Formula: C₂₃H₂₃NO₄
Molecular Weight: 377.43
Catalog: Signaling Pathways Immunology/Inflammation Complement System
Create Date: 2019-06-30 20:40:15
Modify Date: 2024-01-10 07:47:12
FD-IN-1 (Compound 12) is a factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5µM, respectively[1].

Name	FD-IN-1

Description	FD-IN-1 (Compound 12) is a factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5µM, respectively[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Complement System Research Areas >> Inflammation/Immunology
References	[1]. Karki RG, et al. Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. J Med Chem. 2019 May 9;62(9):4656-4668.

Molecular Formula	C₂₃H₂₃NO₄
Molecular Weight	377.43