2308497-58-5

2308497-58-5 structure

Name: FGFR1/DDR2 inhibitor 1
Chemical Name: FGFR1/DDR2 inhibitor 1
CAS Number: 2308497-58-5
Molecular Formula: C₂₈H₂₂F₃N₅O
Molecular Weight: 501.50
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2019-06-30 19:39:15
Modify Date: 2024-01-03 22:41:58
FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively[1].

Name	FGFR1/DDR2 inhibitor 1

Description	FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	IC50: 31.1 nM (FGFR1), 108.4 nM (KG-1), 3.2 nM (DDR2)[1].
References	[1]. Wang Q, et al. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem. 2019 Feb 1;163:671-689.

Molecular Formula	C₂₈H₂₂F₃N₅O
Molecular Weight	501.50