FGFR1/DDR2 inhibitor 1

Modify Date: 2024-01-03 22:41:58

FGFR1/DDR2 inhibitor 1 Structure
FGFR1/DDR2 inhibitor 1 structure
Common Name FGFR1/DDR2 inhibitor 1
CAS Number 2308497-58-5 Molecular Weight 501.50
Density N/A Boiling Point N/A
Molecular Formula C28H22F3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FGFR1/DDR2 inhibitor 1


FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively[1].

 Names

Name FGFR1/DDR2 inhibitor 1

 FGFR1/DDR2 inhibitor 1 Biological Activity

Description FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively[1].
Related Catalog
Target

IC50: 31.1 nM (FGFR1), 108.4 nM (KG-1), 3.2 nM (DDR2)[1].

References

[1]. Wang Q, et al. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem. 2019 Feb 1;163:671-689.

 Chemical & Physical Properties

Molecular Formula C28H22F3N5O
Molecular Weight 501.50
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