Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Mcl1-IN-9
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Purity: 98.0%
Stocking Period: 10 Day
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1810769-31-3

1810769-31-3 structure

1810769-31-3 structure

Name: Mcl1-IN-9
Chemical Name: Mcl1-IN-9
CAS Number: 1810769-31-3
Molecular Formula: C₃₇H₃₉ClN₄O₄
Molecular Weight: 639.18
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2019-06-30 12:43:15
Modify Date: 2024-01-05 12:40:25
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].

Name	Mcl1-IN-9

Description	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:0.03 nM (Ki)
In Vitro	Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].
In Vivo	Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].
References	[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.

Molecular Formula	C₃₇H₃₉ClN₄O₄
Molecular Weight	639.18

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