1353564-66-5
1353564-66-5 structure
- Name: NP-12
- Chemical Name: NP-12
- CAS Number: 1353564-66-5
- Molecular Formula: C142H225N39O49
- Molecular Weight: 3262.00
- Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
- Create Date: 2019-06-29 15:05:05
- Modify Date: 2024-01-10 17:16:39
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NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy[1].
| Name | NP-12 |
|---|
| Description | NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy[1]. |
|---|---|
| Related Catalog | |
| Target |
PD-1[1] |
| In Vitro | NP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1]. NP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1]. NP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1]. |
| References |
| Molecular Formula | C142H225N39O49 |
|---|---|
| Molecular Weight | 3262.00 |