NP-12

Modify Date: 2024-01-10 17:16:39

NP-12 structure	Common Name	NP-12
	CAS Number	1353564-66-5	Molecular Weight	3262.00
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄₂H₂₂₅N₃₉O₄₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NP-12

NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy[1].

Name	NP-12

Description	NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Target	PD-1[1]
In Vitro	NP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1]. NP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1]. NP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1].
References	[1]. Sasikumar PG， et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18(6):1081-1091.

Molecular Formula	C₁₄₂H₂₂₅N₃₉O₄₉
Molecular Weight	3262.00