1416663-77-8
1416663-77-8 structure
- Name: RO-5963
- Chemical Name: RO-5963
- CAS Number: 1416663-77-8
- Molecular Formula: C24H21ClF2N4O5
- Molecular Weight: 518.90
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2019-06-29 12:03:05
- Modify Date: 2024-01-09 14:47:39
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RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1].
| Name | RO-5963 |
|---|
| Description | RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: ~17 nM (p53-MDM2), ~24 nM (p53-MDMX)[1] |
| In Vitro | RO-5963 (10-20 μM; 48 hours) shows much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines[1]. RO-5963 (10 μM, 24 hours) effectively activats p53 and elevates p21 and MDM2 levels[1]. Apoptosis Analysis[1] Cell Line: ZR75-30, MCF7 cells Concentration: 10, 20 μM Incubation Time: 48 hours Result: Potently showed apoptotic activity. Western Blot Analysis[1] Cell Line: LNCap, U2OS, RKO, A489, 22Rv1, HCT116, H460, LOX, MCF7, A549, G401 cells Concentration: 10 μM Incubation Time: 24 hour Result: Effectively activated p53 and elevated p21 and MDM2 levels. |
| References |
| Molecular Formula | C24H21ClF2N4O5 |
|---|---|
| Molecular Weight | 518.90 |