1275582-97-2

1275582-97-2 structure

Name: ACX-362E
Chemical Name: ACX-362E
CAS Number: 1275582-97-2
Molecular Formula: C₁₈H₂₀Cl₂N₆O₂
Molecular Weight: 423.30
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2019-08-04 09:49:58
Modify Date: 2025-08-25 20:09:18
ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1].

Name	ACX-362E

Description	ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC50: 2 μg/mL (C. difficile)[1]
References	[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.

Molecular Formula	C₁₈H₂₀Cl₂N₆O₂
Molecular Weight	423.30