2097132-93-7

2097132-93-7 structure

Name: BLU-667 trans form
Chemical Name: cis-Pralsetinib
CAS Number: 2097132-93-7
Molecular Formula: C₂₇H₃₂FN₉O₂
Molecular Weight: 533.60
Catalog: Research Areas Cancer
Create Date: 2019-08-03 23:22:59
Modify Date: 2024-01-05 23:13:11
cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2].

Name	cis-Pralsetinib

Description	cis-Pralsetinib (cis-Blu667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types[1][2].
Related Catalog	Research Areas >> Cancer
Target	IC50: 0.4 nM (WT RET), 0.3 nM (RET V804L), 0.4 nM (RET V804M), 0.4 nM (RET M918T), 0.4 nM (CCDC6-RET)[2]
References	[1]. http://www.blueprintmedicines.com/wp-content/uploads/2017/10/BLU-667-EORTC-2017-BPM.pdf [2]. Subbiah V, et al. Precision Targeted Therapy With BLU-667 for RET-Driven Cancers. American Association for Cancer Research. 10.1158/2159-8290.CD-18-0338.

Molecular Formula	C₂₇H₃₂FN₉O₂
Molecular Weight	533.60