Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Methyl Ester N-[6-(3-Cyclopropyl-5-methyl-1H-pyrazol-4-yl)-1H-indazol-4-yl]carbamic Acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Ds28120313
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2146177-09-3

2146177-09-3 structure

2146177-09-3 structure

Name: Ds28120313
Chemical Name: DS28120313
CAS Number: 2146177-09-3
Molecular Formula: C₁₆H₁₇N₅O₂
Molecular Weight: 311.34
Catalog: Research Areas Inflammation/Immunology
Create Date: 2019-08-03 19:16:58
Modify Date: 2024-01-06 11:48:07
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1].

Name	DS28120313

Description	DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 0.093 μM (hepcidin production)[1]
In Vivo	DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].
References	[1]. Fukuda T, et al. Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5252-5257.

Molecular Formula	C₁₆H₁₇N₅O₂
Molecular Weight	311.34

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