DC Chemicals Limited
China
Product Name: VU 0650991
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Purity: 98.0%
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Contact: Tony Cao

488097-06-9

488097-06-9 structure

488097-06-9 structure

Name: VU 0650991
Chemical Name: GLP-1R Antagonist 1
CAS Number: 488097-06-9
Molecular Formula: C₁₆H₁₁ClF₆N₄O₂
Molecular Weight: 440.73
Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
Create Date: 2019-08-04 08:12:59
Modify Date: 2024-01-12 22:02:01
GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].

Name	GLP-1R Antagonist 1

Description	GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Target	IC50: 650 nM (GLP-1R)[1].
References	[1]. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.

Molecular Formula	C₁₆H₁₁ClF₆N₄O₂
Molecular Weight	440.73