2083621-90-1

2083621-90-1 structure

Name: MBM-17
Chemical Name: MBM-17
CAS Number: 2083621-90-1
Molecular Formula: C₂₈H₂₈N₆O₂
Molecular Weight: 480.56
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-08-03 19:46:58
Modify Date: 2025-09-10 14:57:57
MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].

Name	MBM-17

Description	MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]
In Vitro	MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].
References	[1]. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.

Molecular Formula	C₂₈H₂₈N₆O₂
Molecular Weight	480.56