848647-56-3
848647-56-3 structure
- Name: J-2156
- Chemical Name: J-2156
- CAS Number: 848647-56-3
- Molecular Formula: C24H28N4O4S
- Molecular Weight: 468.57
- Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
- Create Date: 2019-09-07 13:45:19
- Modify Date: 2024-01-10 19:16:42
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J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively[1].
| Name | J-2156 |
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| Description | J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 0.05 nM (human SST4) and 0.07 nM (rat SST4)[1] |
| In Vivo | J-2156 (1-10 mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats[1]. Animal Model: BCIBP-rats[1] Dosage: 1, 3, 10 mg/kg Administration: I.p.; for 3 hours Result: Had anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats. |
| References |
| Molecular Formula | C24H28N4O4S |
|---|---|
| Molecular Weight | 468.57 |