1941168-65-5

1941168-65-5 structure

Name: MC-Sq-Cit-PAB-Dolastatin10
Chemical Name: MC-Sq-Cit-PAB-Dolastatin10
CAS Number: 1941168-65-5
Molecular Formula: C₇₀H₁₀₅N₁₂O₁₂S
Molecular Weight: 1338.72
Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
Create Date: 2019-09-09 20:52:48
Modify Date: 2024-01-08 16:33:05
MC-Sq-Cit-PAB-Dolastatin10 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Sq-Cit-PAB-Dolastatin10 is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2].

Name	MC-Sq-Cit-PAB-Dolastatin10

Description	MC-Sq-Cit-PAB-Dolastatin10 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Sq-Cit-PAB-Dolastatin10 is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
In Vitro	ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.385 nM, and ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC50s of 3.19 nM, 1.52 nM, respectively[1].
References	[1]. FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1. [2]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.

Molecular Formula	C₇₀H₁₀₅N₁₂O₁₂S
Molecular Weight	1338.72