MC-Sq-Cit-PAB-Dolastatin10
Modify Date: 2024-01-08 16:33:05
MC-Sq-Cit-PAB-Dolastatin10 structure
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Common Name | MC-Sq-Cit-PAB-Dolastatin10 | ||
|---|---|---|---|---|
| CAS Number | 1941168-65-5 | Molecular Weight | 1338.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C70H105N12O12S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MC-Sq-Cit-PAB-Dolastatin10MC-Sq-Cit-PAB-Dolastatin10 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Sq-Cit-PAB-Dolastatin10 is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2]. |
| Name | MC-Sq-Cit-PAB-Dolastatin10 |
|---|
| Description | MC-Sq-Cit-PAB-Dolastatin10 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Sq-Cit-PAB-Dolastatin10 is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2]. |
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| Related Catalog | |
| In Vitro | ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.385 nM, and ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC50s of 3.19 nM, 1.52 nM, respectively[1]. |
| References |
| Molecular Formula | C70H105N12O12S |
|---|---|
| Molecular Weight | 1338.72 |