1410737-34-6

1410737-34-6 structure

1410737-34-6 structure

Name: MI-1061
Chemical Name: MI-1061
CAS Number: 1410737-34-6
Molecular Formula: C₃₀H₂₆Cl₂FN₃O₄
Molecular Weight: 582.45
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-09-07 19:29:18
Modify Date: 2024-01-09 23:13:22
MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity[1].

Name	MI-1061

Description	MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
Target	IC50: 4.4 nM (MDM2)[1] Ki: 0.16 nM (MDM2)
In Vitro	MI-1061 achieves IC50=100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively, and has IC50>10000 nM in the p53 knockout cell line HCT-116 p53–/–cell line[1].
In Vivo	MI-1061 is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice with oral administration[1].
References	[1]. Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98.

Molecular Formula	C₃₀H₂₆Cl₂FN₃O₄
Molecular Weight	582.45