1228580-11-7
1228580-11-7 structure
- Name: ASP1126
- Chemical Name: ASP1126
- CAS Number: 1228580-11-7
- Molecular Formula: C26H26ClF6NO5
- Molecular Weight: 581.93
- Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
- Create Date: 2020-02-18 11:13:37
- Modify Date: 2025-09-19 18:51:34
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ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].
| Name | ASP1126 |
|---|
| Description | ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1]. |
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| Related Catalog | |
| Target |
EC50: 7.12 nM (hS1P1), 517 nM (hS1P3)[1]. |
| In Vivo | ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival[1]. ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time[1]. Animal Model: ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively[1]. Dosage: 0.2 mg/kg, 1 mg/kg, 5 mg/kg. Administration: Orally once daily for 14 days. Result: Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group). |
| References |
| Molecular Formula | C26H26ClF6NO5 |
|---|---|
| Molecular Weight | 581.93 |