2113650-05-6

2113650-05-6 structure

Name: BMS-1166 hydrochloride
Chemical Name: BMS-1166 hydrochloride
CAS Number: 2113650-05-6
Molecular Formula: C₃₆H₃₄Cl₂N₂O₇
Molecular Weight: 677.57
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2019-10-07 20:13:52
Modify Date: 2024-01-03 20:09:26
BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

Name	BMS-1166 hydrochloride

Description	BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1 Research Areas >> Inflammation/Immunology
Target	IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].
In Vitro	BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].
References	[1]. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. [2]. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.

Molecular Formula	C₃₆H₃₄Cl₂N₂O₇
Molecular Weight	677.57