2270986-66-6

2270986-66-6 structure

Name: CL2 Linker
Chemical Name: CL2 Linker
CAS Number: 2270986-66-6
Molecular Formula: C₆₈H₁₀₃N₁₁O₂₂
Molecular Weight: 1426.61
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2019-10-09 17:52:29
Modify Date: 2024-01-06 10:36:31
CL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

Name	CL2 Linker

Description	CL2 Linker is an ADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology
Target	Alkyl/ether
References	[1]. Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26. [2]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

Molecular Formula	C₆₈H₁₀₃N₁₁O₂₂
Molecular Weight	1426.61