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1279680-68-0

1279680-68-0 structure
1279680-68-0 structure
  • Name: CL2A-SN-38
  • Chemical Name: CL2A-SN-38
  • CAS Number: 1279680-68-0
  • Molecular Formula: C73H97N11O22
  • Molecular Weight: 1480.61
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2019-10-13 22:14:35
  • Modify Date: 2025-08-27 13:35:34
  • CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].

Name CL2A-SN-38
Description CL2A-SN-38, SN-38 (topoisomerase-I inhibitor) derivative, is a peptide linker. CL2A-SN-38 is conjugated to the anti-Trop-2-humanized antibody, SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, provides significant and specific antitumor effects against a range of human solid tumor types[1].
Related Catalog
Target

Alkyl/ether

References

[1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.

Molecular Formula C73H97N11O22
Molecular Weight 1480.61
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