1639351-92-0

1639351-92-0 structure

Name: Mc-Val-Cit-PAB-Cl
Chemical Name: Mc-Val-Cit-PAB-Cl
CAS Number: 1639351-92-0
Molecular Formula: C₂₈H₃₉ClN₆O₆
Molecular Weight: 591.10
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2019-10-07 21:11:52
Modify Date: 2024-01-10 19:56:16
Mc-Val-Cit-PAB-Cl is an ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

Name	Mc-Val-Cit-PAB-Cl

Description	Mc-Val-Cit-PAB-Cl is an ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Alkyl/ether
References	[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.