Mc-Val-Cit-PAB-Cl

Modify Date: 2025-08-26 20:46:55

Mc-Val-Cit-PAB-Cl Structure
Mc-Val-Cit-PAB-Cl structure
Common Name Mc-Val-Cit-PAB-Cl
CAS Number 1639351-92-0 Molecular Weight 591.10
Density N/A Boiling Point N/A
Molecular Formula C28H39ClN6O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mc-Val-Cit-PAB-Cl


Mc-Val-Cit-PAB-Cl is an ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

 Names

Name Mc-Val-Cit-PAB-Cl

 Mc-Val-Cit-PAB-Cl Biological Activity

Description Mc-Val-Cit-PAB-Cl is an ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
Related Catalog
Target

Alkyl/ether

References

[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.

 Chemical & Physical Properties

Molecular Formula C28H39ClN6O6
Molecular Weight 591.10
Storage condition -20°C
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