2246380-69-6

2246380-69-6 structure
2246380-69-6 structure
  • Name: MAC glucuronide phenol-linked SN-38
  • Chemical Name: pH-susceptible lactone
  • CAS Number: 2246380-69-6
  • Molecular Formula: C50H54N6O20S
  • Molecular Weight: 1091.06
  • Catalog: Signaling Pathways Antibody-drug Conjugate Drug-Linker Conjugates for ADC
  • Create Date: 2019-10-08 10:24:52
  • Modify Date: 2025-08-27 07:35:00
  • pH-susceptible lactone (Drug linker 1) is a pH-susceptible lactone-linked SN-38 drug linker. pH-susceptible lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].

Name pH-susceptible lactone
Description pH-susceptible lactone (Drug linker 1) is a pH-susceptible lactone-linked SN-38 drug linker. pH-susceptible lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].
Related Catalog
References

[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.

Molecular Formula C50H54N6O20S
Molecular Weight 1091.06
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