MAC glucuronide phenol-linked SN-38

Modify Date: 2024-01-16 10:40:51

MAC glucuronide phenol-linked SN-38 structure	Common Name	MAC glucuronide phenol-linked SN-38
	CAS Number	2246380-69-6	Molecular Weight	1091.06
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₀H₅₄N₆O₂₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MAC glucuronide phenol-linked SN-38

pH-susceptible lactone (Drug linker 1) is a pH-susceptible lactone-linked SN-38 drug linker. pH-susceptible lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].

Name	pH-susceptible lactone

Description	pH-susceptible lactone (Drug linker 1) is a pH-susceptible lactone-linked SN-38 drug linker. pH-susceptible lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC
References	[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072.

Molecular Formula	C₅₀H₅₄N₆O₂₀S
Molecular Weight	1091.06

MAC glucuronide phenol-linked SN-38

Use of MAC glucuronide phenol-linked SN-38

Names

MAC glucuronide phenol-linked SN-38 Biological Activity

Chemical & Physical Properties