Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phortress free base
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Purity: 98.0%
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741241-36-1

741241-36-1 structure

741241-36-1 structure

Name: Phortress free base
Chemical Name: Phortress free base
CAS Number: 741241-36-1
Molecular Formula: C₂₀H₂₃FN₄OS
Molecular Weight: 386.49
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2019-10-06 20:18:38
Modify Date: 2024-01-23 14:14:55
Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity[1]. Phortress free base leads to DNA damage and cell cycle arrest[2].

Name	Phortress free base

Description	Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity[1]. Phortress free base leads to DNA damage and cell cycle arrest[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
References	[1]. Behrsing HP, et al. In vitro exposure of precision-cut lung slices to 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage. Toxicol Sci. 2013 Feb;131(2):470-9. [2]. Trapani V, et al. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells. Br J Cancer. 2003 Feb 24;88(4):599-605.

Molecular Formula	C₂₀H₂₃FN₄OS
Molecular Weight	386.49

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