1874232-80-0
1874232-80-0 structure
- Name: AM-6494
- Chemical Name: AM-6494
- CAS Number: 1874232-80-0
- Molecular Formula: C22H21F2N5O3S
- Molecular Weight: 473.50
- Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
- Create Date: 2019-12-07 20:28:54
- Modify Date: 2025-08-26 19:51:27
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AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1].
| Name | AM-6494 |
|---|
| Description | AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: (BACE1), 18.6 nM (BACE2)[1] |
| References |
| Molecular Formula | C22H21F2N5O3S |
|---|---|
| Molecular Weight | 473.50 |