1387090-01-8

1387090-01-8 structure

Name: DYRKs-IN-1
Chemical Name: DYRKs-IN-1
CAS Number: 1387090-01-8
Molecular Formula: C₃₀H₃₀ClN₇O₄
Molecular Weight: 588.06
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2019-12-08 14:38:19
Modify Date: 2024-01-31 05:37:28
DYRKs-IN-1 (Example 183) is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-1 has antitumor activity[1][2].

Name	DYRKs-IN-1

Description	DYRKs-IN-1 (Example 183) is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively. DYRKs-IN-1 has antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Target	IC50: 9 nM (DYRK1B) and 5 nM (DYRK1A)[2]
In Vitro	DYRKs-IN-1 (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[2].
References	[1]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1 [2]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5.

Molecular Formula	C₃₀H₃₀ClN₇O₄
Molecular Weight	588.06