- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: IACS-8779
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Huang
2243079-26-5
2243079-26-5 structure
- Name: IACS-8779
- Chemical Name: IACS-8779
- CAS Number: 2243079-26-5
- Molecular Formula: C21H25N9O10P2S2
- Molecular Weight: 689.56
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2019-12-07 10:01:54
- Modify Date: 2024-01-06 21:35:34
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IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1].
| Name | IACS-8779 |
|---|
| Description | IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Mice are implanted bilaterally with B16-Ova, and IACS-8779 (compound 1a) is administered at 10 μg dose with three intra-tumoral injections, on one flank only, on day 6, 9, 12 post implantation. While IACS-8779 shows comparable antitumor activity on the injected flank, IACS-8779 achieves superior regression on the untreated tumor in the contralateral flank, suggesting a more significant systemic immune response compared to the benchmark analogs. Treatment with IACS-8779 also results in a higher number of mice cured of both tumors compared to benchmarks[1]. |
| References |
| Molecular Formula | C21H25N9O10P2S2 |
|---|---|
| Molecular Weight | 689.56 |