IACS-8779

Modify Date: 2024-01-06 21:35:34

IACS-8779 structure	Common Name	IACS-8779
	CAS Number	2243079-26-5	Molecular Weight	689.56
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₅N₉O₁₀P₂S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IACS-8779

IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1].

Name	IACS-8779

Description	IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
In Vivo	Mice are implanted bilaterally with B16-Ova, and IACS-8779 (compound 1a) is administered at 10 μg dose with three intra-tumoral injections, on one flank only, on day 6, 9, 12 post implantation. While IACS-8779 shows comparable antitumor activity on the injected flank, IACS-8779 achieves superior regression on the untreated tumor in the contralateral flank, suggesting a more significant systemic immune response compared to the benchmark analogs. Treatment with IACS-8779 also results in a higher number of mice cured of both tumors compared to benchmarks[1].
References	[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.

Molecular Formula	C₂₁H₂₅N₉O₁₀P₂S₂
Molecular Weight	689.56

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: IACS-8779
Price: Negotiable
Purity: 98.0%
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