1706524-94-8
1706524-94-8 structure
- Name: ML00253764 hydrochloride
- Chemical Name: ML-00253764 hydrochloride
- CAS Number: 1706524-94-8
- Molecular Formula: C18H19BrClFN2O
- Molecular Weight: 413.71
- Catalog: Research Areas Cancer
- Create Date: 2019-12-07 20:42:11
- Modify Date: 2025-08-27 09:55:36
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ML-00253764 is a nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 µM and 0.103 µM, respectively. Brain penetrant[1].
| Name | ML-00253764 hydrochloride |
|---|
| Description | ML-00253764 is a nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 µM and 0.103 µM, respectively. Brain penetrant[1]. |
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| Related Catalog | |
| In Vitro | ML-00253764 displaces NDP-α-MSH binding with a mean IC50 of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively[1]. ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes[1]. |
| In Vivo | ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice[1]. ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 ml/kg[1]. Animal Model: CT-26 tumor bearing BALB/c mice[1] Dosage: 3, 10, or 30 mg/kg Administration: Subcutaneous injection; 3, 10, or 30 mg/kg; once daily Result: Reduced tumor-induced weight loss in a mouse model. |
| References |
| Molecular Formula | C18H19BrClFN2O |
|---|---|
| Molecular Weight | 413.71 |