1233748-60-1

1233748-60-1 structure

Name: (Z)-GW 5074
Chemical Name: (Z)-GW 5074
CAS Number: 1233748-60-1
Molecular Formula: C₁₅H₈Br₂INO₂
Molecular Weight: 520.94
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2019-12-08 15:19:19
Modify Date: 2025-08-27 12:23:38
(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].

Name	(Z)-GW 5074

Description	(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for neurodegenerative disorder[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	c-Raf
References	[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.

Molecular Formula	C₁₅H₈Br₂INO₂
Molecular Weight	520.94