150404-10-7
150404-10-7 structure
- Name: QO IIR
- Chemical Name: QO IIR
- CAS Number: 150404-10-7
- Molecular Formula: C15H11NO5
- Molecular Weight: 285.25
- Create Date: 2019-12-20 11:04:48
- Modify Date: 2025-09-17 16:24:22
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QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM; fully reverses the reserpine-induced catalepsy in vivo, demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD.
| Name | QO IIR |
|---|---|
| Synonyms | (E)-3-(3,4-Dihydroxy-2-nitrophenyl)-1-phenylprop-2-en-1-one |
| Description | QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM; fully reverses the reserpine-induced catalepsy in vivo, demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD. |
|---|---|
| References | References 1. Rivas E, et al. Br J Pharmacol. 1999 Apr;126(7):1667-73. 2. Pérez RA, et al. Biochem Pharmacol. 1993 May 25;45(10):1973-81. View Related Products by Target COMT |
| Molecular Formula | C15H11NO5 |
|---|---|
| Molecular Weight | 285.25 |
| Exact Mass | 285.063722 |