1019112-29-8
1019112-29-8 structure
- Name: MK-3577
- Chemical Name: MK-3577
- CAS Number: 1019112-29-8
- Molecular Formula: C30H30ClFN2O3
- Molecular Weight: 521.022
- Create Date: 2020-01-11 10:50:31
- Modify Date: 2024-04-05 22:57:52
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A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM. Diabetes Phase 2 Discontinued
| Name | MK-3577 |
|---|---|
| Synonyms |
β-Alanine, N-[4-[(1S)-1-[(R)-(4-chlorophenyl)(7-fluoro-5-methyl-1H-indol-3-yl)methyl]butyl]benzoyl]-
MK-3577 N-{4-[(1R,2S)-1-(4-Chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)-2-pentanyl]benzoyl}-β-alanine |
| Description | A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM. Diabetes Phase 2 Discontinued |
|---|---|
| References | References 1. Peng JZ, et al. AAPS J. 2014 Nov;16(6):1259-70. View Related Products by Target Glucagon Receptor Diabetes |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 702.4±60.0 °C at 760 mmHg |
| Molecular Formula | C30H30ClFN2O3 |
| Molecular Weight | 521.022 |
| Flash Point | 378.6±32.9 °C |
| Exact Mass | 520.192871 |
| LogP | 7.03 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.626 |