1053172-87-4

1053172-87-4 structure

Name: NC-043
Chemical Name: (5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione
CAS Number: 1053172-87-4
Molecular Formula: C₂₂H₃₀O₄
Molecular Weight: 330.418
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2020-01-11 21:00:50
Modify Date: 2023-01-11 17:14:58
NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association; decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo; inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth.

Name	(5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione
Synonyms	(5β,7α,8α,9β,10α,12α)-7-Hydroxy-19,20-epoxyatis-16-ene-15,20-dione Atis-16-ene-15,20-dione, 18,20-epoxy-7-hydroxy-, (5β,7α,8α,9β,10α,12α)-

Description	NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association; decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo; inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth.
References	References 1. Wang W, et al. Cell Res. 2011 May;21(5):730-40. 2. Yan M, et al. Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197. 3. He X, et al. Cell Discov. 2017 Jan 31;3:17003. View Related Products by Target Beta-catenin