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1197420-11-3

1197420-11-3 structure
1197420-11-3 structure
  • Name: BMS 814580
  • Chemical Name: 6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one
  • CAS Number: 1197420-11-3
  • Molecular Formula: C24H19ClF2N2O4S
  • Molecular Weight: 504.934
  • Catalog: Signaling Pathways GPCR/G Protein MCHR1 (GPR24)
  • Create Date: 2020-01-14 12:24:04
  • Modify Date: 2024-04-02 14:35:00
  • A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in a chronic diet-induced obese model.

Name 6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one
Synonyms Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl]-
MFCD30829296
6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one
Description A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in a chronic diet-induced obese model.
References References 1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR)
Density 1.5±0.1 g/cm3
Boiling Point 691.9±65.0 °C at 760 mmHg
Molecular Formula C24H19ClF2N2O4S
Molecular Weight 504.934
Flash Point 372.3±34.3 °C
Exact Mass 504.072205
LogP 3.71
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.660