1197420-11-3
1197420-11-3 structure
- Name: BMS 814580
- Chemical Name: 6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one
- CAS Number: 1197420-11-3
- Molecular Formula: C24H19ClF2N2O4S
- Molecular Weight: 504.934
- Catalog: Signaling Pathways GPCR/G Protein MCHR1 (GPR24)
- Create Date: 2020-01-14 12:24:04
- Modify Date: 2024-04-02 14:35:00
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A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in a chronic diet-induced obese model.
| Name | 6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one |
|---|---|
| Synonyms |
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(4-chlorophenyl)-3-[4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl]-
MFCD30829296 6-(4-Chlorophenyl)-3-{4-[(3,3-difluoro-1-hydroxycyclobutyl)methoxy]-3-methoxyphenyl}thieno[3,2-d]pyrimidin-4(3H)-one |
| Description | A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM; exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM, dose-dependently reduces body weight in a chronic diet-induced obese model. |
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| References | References 1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 691.9±65.0 °C at 760 mmHg |
| Molecular Formula | C24H19ClF2N2O4S |
| Molecular Weight | 504.934 |
| Flash Point | 372.3±34.3 °C |
| Exact Mass | 504.072205 |
| LogP | 3.71 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.660 |